AJAX Click and Script replay errors 0x800401F3 VUGen hangs

Has anyone seen/figured out/fixed issues where you get the 0x800401F3 error on Things like:
Action.c(85): JavaScript warning (id=167) in line 20: Error: ActiveX-related automation error: Invalid class string CLSIDFromProgID for MSXML2.XMLDOM (HRESULT=0x800401F3). (recorded against IBM's portal -captured / filtered in the attachment).
VUGen hangs when it gets to the last one, does not timeout even after an hour or more, and has to have the STOP icon clicked to end the execution.