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If MPX was installed on x64bit server, the install directory ended up in C:\program files instead of c:\program files (x86).
Open the install directory C:\Program files\Borland\Message Broker 6.8.
Edit the STMessageBroker6.8 config file, change the line "setopt conn_names tcp:_node" to "setopt conn_names tcp:localhost", save the changes.
Also set the STMessageBroker6.8.exe to run in compatibility mode.
Finally close any caliber authors then attempt to open again, the MPX should now work successfully