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The GroupWise client spell-checker easily can be changed from, for example, US English to UK English. But when the client is shut down and restarted it reverts back to the default installation language. Sometimes that is exactly what you want to have happen. But if not, here's how you can change it permanently.
Windows Registry Editor Version 5.00
This can also be run from a login script or pushed out using ZENworks so that all users get the same settings.