The rewrite engine does a decent job of rewriting accelerated URLs as long as they match 100%.
The rewrite engine really needs to be able to automatically rewrite protocol-less URLs (i.e. //www.domain.com/path) that are accelerated.
It also need to efficiently process .js files that contain hard links (i.e. var myvar = '/accelerated/path';) especially where a path-based accelerator is used with "remove path on fill".