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query e- mail address from Groupwise server

Hello,

how can I query our Groupwise Server (Groupwise 2014 SP1 on SLES11 SP3) from our Cisco IronPort email and web security Gateway whether an e-Maill address exist or not. Perhaps over LDAP?
We want to eliminate SPAM-Mails before they reach our Groupwisesystem.

Thanks

Hans-Joachim