I have pretty big flows (content pack size: 820KB), When I try to run debug mode on central, studio looses connection and I have to continue in central. How do i fix this?
I would recommand to increase the studio max memory if you haven't done that already - not really connected with your case though.
as for the actual connection - logs are needed. Depending on the studio version you are using - the logs are located in different places so the actual version might help too. (in general either the studio install folder or in more recent versions: the actual workspace folder has the logs folder with Studio.log in it).