As far as I know, SM do not have compatibility matrix for MS Exchange. However, Connect_IT does and even the latest Connect_IT 9.80 version does not support MS Exchange 2016.
However, that supportability is in the roadmap. Please vote for /it_ops_mgt/itsm/i/sma-x-ideas/support-microsoft-exchange-2016-for-connect-it so that you will get updated on the version of Connect-IT that does support MS Exchange 2016.
It's like what Breno said. SM uses SMTP. It depends on your setup. Some customers uses Connect-IT to handle emails in and out of SM and some do not. If you do, then your Connect-IT will be impacted by Exchange Server.
You can check the latest version of Connect-It here, https://softwaresupport.softwaregrp.com/obsolescence-migrations#tab2 which is 9.8x.
But what you need is the Connect-IT 9.8 compatibility matrix here, https://softwaresupport.softwaregrp.com/doc/KM03073650, Unfortunately, it also does not support Exchange 2016, which was why I checked the Ideas Exchange and pointed you there.
Not sure if it helps but Exchange 2010 reaches its end of support on January 14, 2020, and not August. I assume Connect-IT will support Exchange 2016 before then. You can chase it up via the Ideas Exchange link I posted previously.